the effects of nigella sativa on sickness behavior induced by lipopolysaccharide in male wistar rats

نویسندگان

fatemeh norouzi neurocognitive research center, school of medicine, mashhad university of medical sciences, mashhad, iran

azam abareshi pharmacological research center of medicinal plants, school of medicine, mashhad university of medical sciences, mashhad, iran

akbar anaeigoudari department of physiology, school of medicine, jiroft university of medical sciences, jiroft, iran

mohammad naser shafei neurocognitive research center, school of medicine, mashhad university of medical sciences, mashhad, iran

چکیده

objective: neuroimmune factors contribute on the pathogenesis of sickness behaviors. nigella sativa (ns) has anti-inflammatory, anti-anxiety and anti-depressive effects. in the present study, the effect of ns hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (lps) was investigated. materials and methods: the rats were divided into five groups (n=10 in each): (1) control (saline), (2) lps (1 mg/kg, administered two hours before behavioral tests), (3-5) lps-nigella sativa 100 , 200 and 400 mg/kg (lps-ns 100, lps-ns 200 and lps-ns 400, respectively). open- field (of), elevated plus maze (epm) and forced swimming test (fst) were performed. results: in of, lps reduced the peripheral crossing, peripheral distance, total crossing and total distance compared to control (pconclusion: the results of the present study showed that the hydro-alcoholic extract of ns reduced the lps-induced sickness behaviors in rats. further investigations are required for better understanding the responsible compound (s) and the underlying mechanism(s).

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The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats

Objective: Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. Materials and Methods: The rats were divided into five groups (n=10 in each): (1) control...

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عنوان ژورنال:
avicenna journal of phytomedicine

جلد ۶، شماره ۱، صفحات ۱۰۴-۱۱۶

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